Side effects have seldom been reported in patients treated with intravenous metronidazole. Further studies are needed to determine the frequency and nature of adverse effects likely to be encountered with higher dosage and greater duration of metronidazole treatment, sometimes necessary for the treatment of severe anaerobic infections. Adverse effects which occur commonly with dosage of metronidazole used to treat trichomoniasis and amoebiasis, have included anorexia, nausea, abdominal pain, vomiting, vertigo, tiredness, and dark colouration of the urine.
Less commonly reported side effects have included ataxia, headache, transient and reversible neutropenia, metallic taste, vaginal and urethral burning, gastric irritation, diarrhoea, furred tongue. Peripheral neuropathy has also occurred in a patient treated with I.V. metronidazole for anaerobic infection. Transient epileptiform seizures have reported in a few patients undergoing intensive high dosage metronidazole treatment for radiosensitization.